解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Key to the pathogenicity of several viruses is activation of the canonical nuclear factor-kappaB (NF-kappaB) transcriptional pathway. Subversion of this tightly regulated mechanism is achieved through the production of host mimetic viral proteins that deregulate the transcription process. One such protein is ks-vFLIP ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.04.029
更新日期:2008-06-06 00:00:00
abstract::The interaction of transcription factors with target genes is highly dynamic. Whether the dynamic nature of these interactions is merely an intrinsic property of transcription factors or serves a regulatory role is unknown. Here we have used single-cell fluorescence imaging combined with computational modeling and chr...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.04.021
更新日期:2008-05-23 00:00:00
abstract::In this issue of Molecular Cell, Basak et al. (2008) identify Prl-3 as a p53-inducible gene acting in DNA damage-induced cell-cycle arrest. Both deletion and overexpression of Prl-3 can be cytostatic, adding to a growing list of genes whose expression must be carefully titrated for proper cell proliferation. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.04.006
更新日期:2008-05-09 00:00:00
abstract::By using single-molecule fluorescence resonance energy transfer (smFRET), we observe the real-time dynamic coupling between the ribosome, labeled at the L1 stalk, and transfer RNA (tRNA). We find that an interaction between the ribosomal L1 stalk and the newly deacylated tRNA is established spontaneously upon peptide ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.03.012
更新日期:2008-05-09 00:00:00
abstract::AMPK is a highly conserved sensor of cellular energy status that is activated under conditions of low intracellular ATP. AMPK responds to energy stress by suppressing cell growth and biosynthetic processes, in part through its inhibition of the rapamycin-sensitive mTOR (mTORC1) pathway. AMPK phosphorylation of the TSC...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.03.003
更新日期:2008-04-25 00:00:00
abstract::In a recent issue of Molecular Cell, Jia et al. (2008) demonstrate that time-controlled repression of interferon-induced transcripts depends upon the interaction between an RNA structure in these transcripts and protein domains harbored by a mammalian aminoacyl-tRNA synthetase. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.03.006
更新日期:2008-04-11 00:00:00
abstract::The LTR-retrotransposon Tf1 preserves the coding capacity of its host Schizosaccharomyces pombe by integrating upstream of open reading frames (ORFs). To determine which features of the target sites were recognized by the transposon, we introduced plasmids containing candidate insertion sites into S. pombe and mapped ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.02.016
更新日期:2008-04-11 00:00:00
abstract::Dbh is a Y family translesion DNA polymerase that accurately bypasses some damaged forms of deoxyguanosine, but also generates single-base deletion errors at frequencies of up to 50%, in specific hot spot sequences. We describe preinsertion binary, insertion ternary, and postinsertion binary crystal structures of Dbh ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2008.01.014
更新日期:2008-03-28 00:00:00
abstract::In this issue of Molecular Cell, Hogues et al. (2008) demonstrate a wholesale shift in the key regulatory protein involved in ribosomal protein (RP) synthesis during the evolution of S. cerevisiae and, en passant, raise interesting questions about the relationship between RP genes and telomeres. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.02.008
更新日期:2008-03-14 00:00:00
abstract::Long DNA palindromes are sites of genome instability (deletions, amplification, and translocations) in both prokaryotic and eukaryotic cells. In Escherichia coli, genetic evidence has suggested that they are sites of DNA cleavage by the SbcCD complex that can be repaired by homologous recombination. Here we obtain in ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.12.020
更新日期:2008-03-14 00:00:00
abstract::In this issue of Molecular Cell, Mariner et al. (2008) demonstrate that Alu RNA from a human SINE represses RNA polymerase II transcription during heat shock. This noncoding RNA is the first example of a "protein-like" transcription factor with a distinct modular architecture. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.02.001
更新日期:2008-02-29 00:00:00
abstract::MeCP2 is an essential transcriptional repressor that mediates gene silencing through binding to methylated DNA. Binding specificity has been thought to depend on hydrophobic interactions between cytosine methyl groups and a hydrophobic patch within the methyl-CpG-binding domain (MBD). X-ray analysis of a methylated DN...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.12.028
更新日期:2008-02-29 00:00:00
abstract::Cells undergo apoptosis upon exposure to severe DNA damage stress. Under this condition, p73 is phosphorylated and activated by c-Abl. The transcription coactivator Yap1 binds p73 to generate a complex that escapes p73 proteasomal degradation and recruits p300 to support transcription of proapoptotic genes. However, t...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.12.022
更新日期:2008-02-15 00:00:00
abstract::GATA-1 and GATA-2 control proliferation and differentiation of hematopoietic progenitor cells via transcriptional regulation. In this issue of Molecular Cell, Jing et al. (2008) demonstrate that GATA factor exchange on the Kit locus directs a transcriptional switch by reconfiguring chromatin loops. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2008.01.008
更新日期:2008-02-01 00:00:00
abstract::We used computational algorithms to find conserved sequences in the 3' untranslated region (UTR) of transcripts that exhibited rapid decay in primary human T cells and found that the consensus sequence UGUUUGUUUGU, which we have termed a GU-rich element (GRE), was enriched in short-lived transcripts. Using a tet-off r...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.11.024
更新日期:2008-02-01 00:00:00
abstract::Solving the biological roles of covalent histone modifications, including monoubiquitination of histone H2A, and the molecular mechanisms by which these modifications regulate specific transcriptional programs remains a central question for all eukaryotes. Here we report that the N-CoR/HDAC1/3 complex specifically rec...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.11.002
更新日期:2008-01-18 00:00:00
abstract::A defining feature of centromeres is the presence of the histone H3 variant CENP-A(Cnp1). It is not known how CENP-A(Cnp1) is specifically delivered to, and assembled into, centromeric chromatin. Through a screen for factors involved in kinetochore integrity in fission yeast, we identified Sim3. Sim3 is homologous to ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.10.010
更新日期:2007-12-28 00:00:00
abstract::Cell death, as a foil to cell expansion, has become one of the most intensively studied research areas of modern biology. Almost every aspect of life is intimately enmeshed with the proper regulation of cell death, which either contributes to or forms the basis of most human disease pathogenesis. Now, with our ever-ex...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2007.11.016
更新日期:2007-12-14 00:00:00
abstract::Transcriptional and posttranslational signals are known mechanisms that promote efficient responses to DNA damage. We have identified Saccharomyces cerevisiae tRNA methyltransferase 9 (Trm9) as an enzyme that prevents cell death via translational enhancement of DNA damage response proteins. Trm9 methylates the uridine...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.021
更新日期:2007-12-14 00:00:00
abstract::Peptide release on the ribosome is catalyzed in the large subunit peptidyl transferase center by release factors on recognition of stop codons in the small subunit decoding center. Here we examine the role of the decoding center in this process. Mutation of decoding center nucleotides or removal of 2'OH groups from th...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.015
更新日期:2007-11-30 00:00:00
abstract::Trimethylation of histone H3 on lysine 4 (H3K4me3) localizes near the 5' region of genes and is tightly associated with active loci. Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumor suppressor family, directly recognize this lysine methyl mark. However, how H3K4me3 recognition participates in active tra...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.11.010
更新日期:2007-11-30 00:00:00
abstract::A truly groundbreaking paper by Pisarev et al. (2007), recently published in Cell, has solved a wide gap in our knowledge of eukaryotic mRNA translation, by elucidating how ribosomes are released from mRNA after the termination step. ...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2007.10.014
更新日期:2007-11-09 00:00:00
abstract::Homologous recombination is essential for preserving genome integrity. Joining of homologous DNA molecules through strand exchange, a pivotal step in recombination, is mediated by RAD51. Here, we identify RAD51AP1 as a RAD51 accessory protein that specifically stimulates joint molecule formation through the combinatio...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.08.025
更新日期:2007-11-09 00:00:00
abstract::During muscle regeneration, the mechanism integrating environmental cues at the chromatin of muscle progenitors is unknown. We show that inflammation-activated MKK6-p38 and insulin growth factor 1 (IGF1)-induced PI3K/AKT pathways converge on the chromatin of muscle genes to target distinct components of the muscle tra...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.08.021
更新日期:2007-10-26 00:00:00
abstract::Mirtrons are alternative precursors for microRNA biogenesis that were recently described in invertebrates. These short hairpin introns use splicing to bypass Drosha cleavage, which is otherwise essential for the generation of canonical animal microRNAs. Using computational and experimental strategies, we now establish...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.028
更新日期:2007-10-26 00:00:00
abstract::The Latin word "facultas" literally means "opportunity." Facultative heterochromatin (fHC) then designates genomic regions in the nucleus of a eukaryotic cell that have the opportunity to adopt open or compact conformations within temporal and spatial contexts. This review focuses on the molecular and functional aspec...
journal_title:Molecular cell
pub_type: 杂志文章,评审
doi:10.1016/j.molcel.2007.09.011
更新日期:2007-10-12 00:00:00
abstract::The Mre11-Rad50-Nbs1 (MRN) complex is a primary sensor of DNA double-strand breaks (DSBs). Upon recruitment to DSBs, it plays a critical role in catalyzing 5' --> 3' single-strand resection that is required for repair by homologous recombination (HR). Unknown mechanisms repress HR in G1 phase of the cell cycle during ...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.09.009
更新日期:2007-10-12 00:00:00
abstract::How proteasomal ATPases stimulate the gate opening of 20S proteasomes is a longstanding question. In the September 7 issue of Molecular Cell, Smith et al. (2007) describe the conserved "HbYX" motif as the key to proteasome gate opening. ...
journal_title:Molecular cell
pub_type: 评论,杂志文章
doi:10.1016/j.molcel.2007.09.001
更新日期:2007-09-21 00:00:00
abstract::Microtubule plus end binding proteins (+TIPs) localize to the dynamic plus ends of microtubules, where they stimulate microtubule growth and recruit signaling molecules. Three main +TIP classes have been identified (XMAP215, EB1, and CLIP-170), but whether they act upon microtubule plus ends through a similar mechanis...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.07.023
更新日期:2007-09-21 00:00:00
abstract::A major unresolved question in messenger RNA translation is how ribosomal release factors terminate protein synthesis. Class 1 release factors decode stop codons and trigger hydrolysis of the bond between the nascent polypeptide and tRNA some 75 A away from the decoding site. While the gross features of the release fa...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.06.032
更新日期:2007-09-07 00:00:00
abstract::Cockayne syndrome group B (CSB) protein plays a role in both transcription-coupled DNA repair and transcriptional regulation of all three classes of nuclear RNA polymerases. Here we show that a complex consisting of CSB, RNA polymerase I (Pol I), and histone methyltransferase G9a is present at active rRNA genes. G9a m...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.06.021
更新日期:2007-08-17 00:00:00
abstract::In yeast, histone H3/H4 exchange independent of replication is poorly understood. Here, we analyzed the deposition of histone H3 molecules, synthesized during G1, using a high-density microarray histone exchange assay. While we found that H3 exchange in coding regions requires high levels of transcription, promoters e...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.07.011
更新日期:2007-08-03 00:00:00
abstract::Histone deacetylase 6 (HDAC6) is a tubulin-specific deacetylase that regulates microtubule-dependent cell movement. In this study, we identify the F-actin-binding protein cortactin as a HDAC6 substrate. We demonstrate that HDAC6 binds cortactin and that overexpression of HDAC6 leads to hypoacetylation of cortactin, wh...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.05.033
更新日期:2007-07-20 00:00:00
abstract::The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family. Recombinant Rrp44 and the purified TRAMP polyadenylation complex each specifically recognize...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.06.006
更新日期:2007-07-20 00:00:00
abstract::Using genome-wide approaches, we have elucidated the regulatory circuitry governed by the XBP1 transcription factor, a key effector of the mammalian unfolded protein response (UPR), in skeletal muscle and secretory cells. We identified a core group of genes involved in constitutive maintenance of ER function in all ce...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.06.011
更新日期:2007-07-06 00:00:00
abstract::Transcription and splicing are functionally coupled, resulting in highly efficient splicing of RNA polymerase II (RNAP II) transcripts. The mechanism involved in this coupling is not known. To identify potential coupling factors, we carried out a comprehensive proteomic analysis of immunopurified human RNAP II, identi...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.05.036
更新日期:2007-06-22 00:00:00
abstract::ComS is an antiadaptor protein that binds to MecA, displacing the competence transcription factor ComK. This protects ComK from degradation by the ClpCP protease and turns on the switch leading to bistable gene expression. Here we identify the motifs on ComK and ComS that mediate binding to MecA, and we show that they...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.05.011
更新日期:2007-06-08 00:00:00
abstract::Proteins are translocated across membranes through a channel that is formed by the prokaryotic SecY or eukaryotic Sec61 complex. The crystal structure of the SecY channel from M. jannaschii revealed a plug domain that appears to seal the channel in its closed state. However, the role of the plug remains unclear, parti...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.05.002
更新日期:2007-05-25 00:00:00
abstract::The mechanisms by which telomeres are distinguished from DNA double-strand breaks are poorly understood. Here we have defined the minimal requirements for the protection of telomeric DNA ends from nonhomologous end-joining (NHEJ). Neither long, single-stranded overhangs nor t loop formation is essential to prevent NHE...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.03.023
更新日期:2007-05-11 00:00:00
abstract::ATP is required for nucleation of actin filament branches by Arp2/3 complex, but the influence of ATP binding and hydrolysis are poorly understood. We determined crystal structures of bovine Arp2/3 complex cocrystallized with various bound adenine nucleotides and cations. Nucleotide binding favors closure of the nucle...
journal_title:Molecular cell
pub_type: 杂志文章
doi:10.1016/j.molcel.2007.04.017
更新日期:2007-05-11 00:00:00